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・ Dr. Z
・ Dr. Z Amplification
・ Dr. Zeus Inc.
・ Dr. Ziauddin Group of Hospitals
・ Dr. Zitbag's Transylvania Pet Shop
・ Dr. Zoe Today
・ Dr. Zonk and the Zunkins
・ Dr. Ángel Gallardo Provincial Natural Sciences Museum
・ Dr.Amitabha Bhattacharya
・ Dr.Fill
・ Dr.Fixit
・ Dr.I
・ Dr.Rintarō
・ DR1
・ DR1 (car)
DR1 (gene)
・ DR1 diesel train
・ DR10
・ DR2
・ DR3
・ DR3 (disambiguation)
・ Dr30 battery
・ DR37-P
・ DR5
・ Dr5 chrome
・ DR503
・ DRA
・ Dra dit pepparn växer
・ Dra' Abu el-Naga'
・ Draa Errich


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DR1 (gene) : ウィキペディア英語版
DR1 (gene)

Protein Dr1 is a protein that in humans is encoded by the ''DR1'' gene.〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1810 )
== Function ==

This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.〔

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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